Clinical Trials

Clinical trials allow us to offer cutting-edge technologies to our patients, develop novel treatments, and generate evidence to inform future guidelines. Through the optimized clinical trial infrastructure at Northwell Health led by Dr. Christina Brennan, and expert research team at Lenox Hill Hospital, we are proud to contribute to groundbreaking discoveries.

Industry-Sponsored Clinical Trials

Catheter Ablation for AF

  • Evaluate post-market safety and efficacy of Farapulse catheter for paroxysmal AF.

    Sponsor: Boston Scientific

  • Evaluate utility of VX1 system for guiding AF ablation.

    Sponsor: Volta

  • Evaluate safety and efficacy of OMNYPULSE PFA catheter for paroxysmal AF.

    Sponsor: Biosense Webster

  • Evaluate safety and efficacy of OMNYPULSE PFA catheter for persistent AF compared to pentaspline catheter.

    Sponsor: Biosense Webster 

  • Evaluate safety and efficacy of Sphere-360 mapping and ablation catheter for AF.

    Sponsor: Medtronic

  • Evaluate safety and efficacy of Abbott PFA catheter for paroxysmal and persistent AF.

    Sponsor: Abbott

  • Evaluate safety and efficacy of Synaptic compliant cryoablation balloon for paroxysmal AF.

    Sponsor: Synaptic Medical 

  • Evaluate optimal lesion strategy for persistent AF using pentaspline catheter.

    Sponsor: UCSF

  • Explore use of AI-derived software to guide ablation strategy for redo AF.

    Sponsor: Volta

  • Evaluate safety and efficacy of PFA for persistent AF.

    Sponsor: Boston Scientific 

  • Evaluate safety and effectiveness of FARAPULSE as first-line treatment for persistent AF.

    Sponsor: Boston Scientific 

  • Evaluate long-term safety and efficacy of Farapulse catheter for paroxysmal AF (Advent pivotal trial patients).

    Sponsor: Boston Scientific

  • Evaluate safety and efficacy of PFA compared to standard of care for paroxysmal AF.

    Sponsor: Farapulse

  • Evaluate safety and efficacy of PFA for paroxysmal AF.

    Sponsor: Affera

  • Explore use of AI-derived software to guide ablation strategy for persistent AF.

    Sponsor: Volta

  • Evaluate safety and efficacy of multi-electrode RF balloon catheter for paroxysmal AF.

    Sponsor: Biosense Webster

  • Evaluate safety and efficacy of cryoballoon catheter for persistent AF.

    Sponsor: Medtronic

  • Evaluate novel technique using periods of apnea for improved catheter stability during AF ablation.

    Sponsor: Weill Cornell/Houston Methodist

Catheter Ablation for VT

  • Evaluate safety and efficacy of Sphere-9 catheter for ventricular tachycardia.

    Sponsor: Medtronic

  • Evaluate safety and efficacy of Field Medical PFA catheter for scar-related VT.

    Sponsor: Field Medical

  • Evaluate safety and efficacy of Adagio cryoablation catheter for monomorphic VT.

    Sponsor: Adagio Medical

Cardiac Implantable Electronic Device

  • Investigate echocardiographic predictors of adverse outcomes in non-LBBB patients receiving CRT.

    Sponsor: NHLBI

  • Evaluate safety and efficacy of LivIQ system in patients with Class I/II indication for ventricular pacing.

    Sponsor: Biotronik

  • Compare continuous DOAC vs. time-delimited DOAC guided by AF-sensing Smart Watch.

    Sponsor: NIH

  • Explore safety and efficacy of Medtronic products for clinical rhythm management.

    Sponsor: Medtronic

  • Support validation and refinement of model for predicting ICD therapy outcome profiles and death.

    Sponsor: NIH

  • Evaluate clinical and functional trajectories of those with ICDs >5 years.

    Sponsor: NIH

  • Evaluate safety and efficacy of Boston Scientific leadless pacemaker for ATP with subcutaneous ICDs.

    Sponsor: Boston Scientific

  • Evaluate sex-related differences in outcomes in non-ischemic cardiomyopathy patients with CRT devices.

    Sponsor: Biotronik

  • Characterize chronic AV synchrony in subjects with Micra AV device.

    Sponsor: Medtronic

  • Evaluate improvement in HF subjects with AF implanted with two-lead CRT-DX system.

    Sponsor: Biotronik

  • Evaluate if AF patients indicated for CRT benefit from AV junction ablation.

    Sponsor: NIH

  • Evaluate survival benefit of S-ICD in prior MI/diabetes patients with EF 36-50%.

    Sponsor: Boston Scientific

  • Examine safety of ICDs during MRI scans.

    Sponsor: Boston Scientific

  • Determine appropriate programming for subcutaneous ICDs.

    Sponsor: Boston Scientific

  • Evaluate safety and efficacy of VEST wearable defibrillator.

    Sponsor: Zoll

  • Test safety and efficacy of new left ventricular lead.

    Sponsor: Boston Scientific

  • Evaluate extended applications of HeartLogic Heart Failure Diagnostic.

    Sponsor: Boston Scientific

  • Confirm Garmin ECG algorithm can detect/classify AF and normal sinus rhythm from wrist-worn device.

    Sponsor: Garmin International

  • Explore use of investigational algorithm for detecting worsening outcomes in COPD patients.

    Sponsor: Medtronic

Grant Funded Investigator Initiated Clinical Trials

 

  • Evaluate performance of different technologies for repeat catheter ablation for AF.

    Sponsor: Medtronic

  • Compare efficacy of PVI vs. PVI+PWI vs. PVI+PWI+mitral isthmus ablation for persistent AF.

     Sponsor: Medtronic

  • Compare incidence of hemolysis across currently available PFA technologies.

    Sponsor: Medtronic

  • Evaluate technique for catheter localization to determine predictable level of isolation with Pulse Select catheter.

    Sponsor: Medtronic

  • Quantify physiologic response to BAT and correlate with HF symptoms to determine prognostic indicators.

    Sponsor: CVRx

  • Explore temporal relationship between adverse outcomes and CIED data to form prognostic algorithm.

    Sponsor: Biotronik

  • Identify incidence of pacemaker-mediated tachycardia in leadless vs. traditional pacemakers.

    Sponsor: Medtronic

  • Evaluate novel mapping strategy using multi-polar catheter for papillary muscle PVCs.

    Sponsor: Abbott

  • Investigate non-invasive vagal stimulation for PVC suppression.

    Sponsor: Biotel, Parasym

  • Investigate non-invasive 3D electroanatomical mapping approach for papillary muscle PVCs.

    Sponsor: Medtronic

  • Explore incidence of arrhythmias in COPD and temporal relationship with adverse outcomes.

    Sponsor: Biotronik

  • Explore utility of novel non-invasive 3D mapping technique for PVCs.

    Sponsor: Medtronic